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M9470158.TXT
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1994-07-02
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Document 0158
DOCN M9470158
TI Ten years after acquiring an HIV-1 infection: a study in a cohort of
eleven neonates infected by aliquots from a single plasma donation.
DT 9409
AU van den Berg H; Gerritsen EJ; van Tol MJ; Dooren LJ; Vossen JM;
Department of Paediatrics, Leiden University Hospital, The; Netherlands.
SO Acta Paediatr. 1994 Feb;83(2):173-8. Unique Identifier : AIDSLINE
MED/94251071
AB We present data from a 10-year follow-up study of 11 children who had
been infected in the neonatal period by small aliquots of plasma from a
single donation. Three of the children died within the first 2.5 years
of life, 5 other children died between 6.2 and 11 years after infection
and 3 are alive at present. The latter children are classified as P1B
(asymptomatic), P2A (non-specific findings) and P2B (neurological
changes). All infected children showed progressive decline of cellular
immunity. Immunoglobulin levels in serum were increased in the majority
of children for prolonged periods and homogeneous immunoglobulin
components were present. The severity of the disease was related neither
to the clinical condition of the infants in the neonatal period nor to
the volume of transfused plasma, the interval between freezing and
thawing of the plasma, gestational age at birth and age at transfusion.
Coinciding infections with other viruses had no impact on disease
progression during the follow-up period of 10 years.
DE *Blood Donors Blood Transfusion/*ADVERSE EFFECTS Child Follow-Up
Studies Human HIV Infections/IMMUNOLOGY/*TRANSMISSION *HIV-1
Immunity, Cellular Immunoglobulins/BLOOD Infant, Newborn Prognosis
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).